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Anticoagulants: An Essential Class of Drugs for Thrombotic Disorders
Anticoagulant discovered and remains an important choice for parenteral (injected) administration. It acts by accelerating the effect of antithrombin, a natural clotting inhibitor in blood. When heparin binds to antithrombin, it causes a conformational change that greatly increases the inhibitory activity of antithrombin against clotting factors such as thrombin and factor Xa. Heparin's effect is rapid in onset but also easily reversible by agents like protamine sulfate.
