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Human studies are required to confirm the positive effects within vitro plus pet designs. Upcoming research needs to be dedicated to the actual understanding of dose/flavonoid intake-response romantic relationship with pharmacokinetic studies, considering appropriate biomarkers regarding consumption. Long-term eating interventions should observe consequences on markers of late service as well as the possible deterring results of these substances in long-term inflammation-related ailments. (c) This year IUBMB Lifestyle, 66(14):745-758,