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Originate Tissue 2009; 29: 2312-2319An operating 1,Two,Three or more,4-tetrahydroisoquinoline (THIQ)-mediated combination involving 1,3-disubstituted allenes coming from terminal alkynes and also aldehydes under mild conditions in the existence of CuBr 1st after which ZnI2 had been described. This particular telescoped allene activity reaction includes three straight measures as well as side effects: first, a room-temperature CuBr-catalyzed combination