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Aims. To gauge the effects from the ET-receptor antagonist bosentan on epidermis fibrosis and operation throughout patients with SSc. Methods. With this potential, open-label, non-comparative test, you use 12 sufferers with SSc received 58.5mg involving bosentan two times a day with regard to A month and after that 125mg two tmes a day for twenty five several weeks. The primary endpoint ended up b