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Since statins inhibit HMG-CoA reductase and therefore get a new concentration of isoprenoid pyrophosphates, we've got tested the particular speculation that will statins will lead to a decrease in AG renal proximal tubule piling up as well as cytotoxicity. Gentamicin accrued within cultured proximal tubule extracted opossum kidney (OK) cellular material as well as led to dose- and also time-dependent cellular dying which has been limited simply by non-toxic amounts associated with simvastatin (IC(5 1.Three or more mu M), rosuvastatin