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The regio-specific hydroxylation with the 4th N-methyl leucine with the immunosuppressive adviser cyclosporin A new (CsA) was once suggested to be mediated by way of a special cytochrome P450 hydroxylase (CYP), CYP-sb21 from the rare actinomycetes Sebekia benihana. Curiously, a different rare actinomycetes species, Pseudonocardia autotrophica, was found to get a different regio-selectivity, the preferential hydroxylation on the 9th N-methyl leucine of CsA. Via an inside silico research whole genome regarding G. autotrophica, all of us exp